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KMID : 0043319930160010071
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Archives of Pharmacal Research
1993 Volume.16 No. 1 p.71 ~ p.74
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Adenosine Triphosphate-Induced Gastric Cytoprotection Against Ulcerogenic Effects of Hypotherimic Restraint Stress and Diclofenac in Rats
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Shoka AAE
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Abstract
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The protective effect of adenosine triphosphate (ATP) on gastric ulcer induced in rats has been studied. Gastric ulceration was induced by hypothermic restraint stress or diclofenac sodium. Gastric acid secretion and mucosal injury produced by the hypothermic restraint stress was greater as compared with those produced by diclofenac sodium. ATP significantly reduced area of injury, however, increased cyclic adenosine monophosphate (cATP) content. Administration of dipyridamole along with ATP did not change the total lesion area in both models when compared to ATP alone. Aminophylline antagonized the protective effect of ATP on the injured area. Famotidine was found to be effective in reducing gastric acid output as well as the total injured area without any change in cAMP content when given along with ATP.
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